Antipathogenic Efficacy and Hemolytic Activity of Calotropis procera Leaves

The work delt with the growth-inhibitory impact of methanolic extract of Calotropis procera leaves on five pathogenic bacteria, analysed by agar diffusion and broth dilution methods. By agar diffusion method, the extract was found very effective against B. subtilis (MIC= 2.5 mg), while moderate activity was noted against P. mirabilis (MIC= 5 mg). Zone of inhibition was not found for P. aeruginosa, S. aureus and S. typhi for the concentrations screened. MIC was found 9 and 8 mg for S. aureus and S. typhi respectively by broth dilution method. The haemolytic activity exhibited by the crude extract showed time and concentration dependence. The present findings suggested that Calotropis procera is a potential source of antimicrobial compounds.